- (Aryl or heteroaromatic methyl)-2,2'-bi-1H-imidazoles and their use as anti-hypertensive agents
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This invention relates to novel (aryl or heteroaromatic methyl)-2,2'-1H-biimidazoles; to a process for their production comprising of reacting an appropriate alpha-brominated or alpha-chlorinated, substituted or non-substituted, methylated monoaromatic ri
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- A One Step Synthesis of 4-Substituted Imidazoles. An Important Observation When N-Alkylating Imidazoles
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Imidazoles substituted in the 2-position with methyl, 1e, phenyl, 1a, 2-imidazole, 1b-d, or t-butyldiphenylsilyl, 1f, react with soft electrophiles 2 to give modest yields of 4(5)-C-alkylated-imidazoles 3 and N-alkylated products 5.These two products are readily separated by flash chromatography.
- Whitten, Jeffrey P.,Matthews, Donald P.,McCarthy, James R.,Barbuch, Robert J.
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p. 1845 - 1847
(2007/10/02)
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