Low catalyst loadings in olefin metathesis: Synthesis of nitrogen heterocycles by ring-closing metathesis
(Chemical Equetion Presentation) A series of ruthenium catalysts have been screened under ring-closing metathesis (RCM) conditions to produce five-, six-, and seven-membered carbamate-protected cyclic amines. Many of these catalysts demonstrated excellent RCM activity and yields with as low as 500 ppm catalyst loadings. RCM of the five-membered carbamate series could be run neat, the six-membered carbamate series could be run at 1.0 M, and the seven-membered carbamate series worked best at 0.2-0.05 M.
Kuhn, Kevin M.,Champagne, Timothy M.,Hong, Soon Hyeok,Wei, Wen-Hao,Nickel, Andrew,Lee, Choon Woo,Virgil, Scott C.,Grubbs, Robert H.,Pederson, Richard L.
supporting information; experimental part
p. 984 - 987
(2010/06/15)
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