1211580-87-8Relevant articles and documents
Compound, pharmaceutical composition, KDM5C inhibitor and antidepressant
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Paragraph 0064; 0069, (2021/01/21)
PROBLEM TO BE SOLVED: To provide a compound having a strong KDM5C inhibitory action, and an antidepressant. SOLUTION: The present invention provides a triazole-4-ylpyridine compound represented by the following formula. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues
Patrick, Donald A.,Bakunov, Stanislav A.,Bakunova, Svetlana M.,Wenzler, Tanja,Brun, Reto,Tidwell, Richard R.
, p. 559 - 576 (2014/01/17)
Fifty novel prodrugs and aza-analogues of 3,5-bis(4-amidinophenyl)isoxazole and its derivatives were prepared. Eighteen of the 24 aza-analogues exhibited IC50 values below 25 nM against Trypanosoma brucei rhodesiense or Plasmodium falciparum. S