cas 121219-12-3, 4-Pentylbenzeneboronic acid | Articles data ｜lookchem

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121219-12-3

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Sequential one-pot access to molecular diversity through aniline aqueous borylation
On the basis of our recently reported aniline aqueous borylation, molecular diversity was achieved in a one-pot process by combining other reactions such as esterification, Suzuki-Miyaura coupling, hydrogenolysis, or Petasis borono-Mannich.
Erb, William,Albini, Mathieu,Rouden, Jacques,Blanchet, Jrme
p. 10568 - 10580
(2015/01/08)

Design and synthesis of boronic acid inhibitors of endothelial lipase
Endothelial lipase (EL) and lipoprotein lipase (LPL) are homologous lipases that act on plasma lipoproteins. EL is predominantly a phospholipase and appears to be a key regulator of plasma HDL-C. LPL is mainly a triglyceride lipase regulating (V)LDL levels. The existing biological data indicate that inhibitors selective for EL over LPL should have anti-atherogenic activity, mainly through increasing plasma HDL-C levels. We report here the synthesis of alkyl, aryl, or acyl-substituted phenylboronic acids that inhibit EL. Many of the inhibitors evaluated proved to be nearly equally potent against both EL and LPL, but several exhibited moderate to good selectivity for EL.
O'Connell, Daniel P.,Leblanc, Daniel F.,Cromley, Debra,Billheimer, Jeffrey,Rader, Daniel J.,Bachovchin, William W.
p. 1397 - 1401
(2012/03/26)

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Chemical Properties

Appearance/Colour :tan powder
Melting Point: 290-295 °C(lit.)
Boiling Point: 328 °C at 760 mmHg
Flash Point:152.2 °C
Density: 1.01 g/cm³
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
Vapor Pressure: 7.85E-05mmHg at 25°C
Refractive Index: 1.509
PKA: 8.87±0.10(Predicted)
BRN: 4782754
PSA: 40.46000
LogP: 1.09910

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