Compounds of the formula (I) and pharmaceutically acceptable salts thereof, wherein Q1 and R1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of various diseases and conditions that respond to treatment by inhibition of tyrosine kinases.
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Page/Page column 135
(2008/06/13)
Syntheses in the nitrogen π-deficient heterocycles series using a barbier type reaction under sonication. Diazines. Part 29
Barbier type reaction with lithium metal has been tested under sonication on pyridines, a cinnoline and on various diazines. This very convenient method allows a very fast and smooth functionalization of these heterocycles. (C) 2000 Elsevier Science Ltd.
Leprêtre, Anne,Turck, Alain,Plé, Nelly,Quéguiner, Guy
p. 3709 - 3715
(2007/10/03)
First study of syntheses and reactivity of Grignard compounds in the diazine series. Diazines. Part 27
A preparation of Grignard derivatives of diazines is described using a halogen magnesium exchange reaction. This convenient method allows the functionalization of these rings at 0°C or even room temperature.
Leprêtre,Turck,Plé,Knochel,Quéguiner
p. 265 - 273
(2007/10/03)
A New Route to 2,3-Disubstituted Pyrazines; Regioselective Metalation of Chloropyrazine
Chloropyrazine is regioselectively metalated by lithium amides in tetrahydrofuran to give 3-chloro-2-lithiopyrazine.The reaction of this lithio derivative with electrophiles can either be performed in situ (with the electrophile, e.g., chlorotrimethylsila
Turck, A.,Mojovic, L.,Queguiner, G.
p. 881 - 884
(2007/10/02)
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