Neuronal growth promoting sesquiterpene-neolignans; Syntheses and biological studies
The use of small molecules that can promote neuronal growth represents a promising approach to regenerative science. Along these lines we have developed separate short or modular syntheses of the natural products caryolanemagnolol and clovanemagnolol, sma
Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol
The use of small molecule surrogates of growth factors that directly or indirectly promote growth represents an attractive approach to regenerative medicine. With synthetic access to clovanemagnolol, a small molecule initially isolated from the bark of th
Khaing, Zin,Kang, Danby,Camelio, Andrew M.,Schmidt, Christine E.,Siegel, Dionicio
supporting information; experimental part
p. 4808 - 4812
(2011/09/21)
Biomimetic syntheses of the neurotrophic natural products caryolanemagnolol and clovanemagnolol
"Chemical Equation Presented" Separate short and modular syntheses of the isomeric natural products caryolanemagnolol and clovanemagnolol have been achieved starting from commercially available (-)-caryophyllene. The postulated biosynthetic pathways guided the syntheses of the neuroregenerative small molecules allowing their assembly In as few as two steps.