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2-Bromo-3-nitro-5-(trifluoromethyl)pyridine is a chemical compound with the molecular formula C6H2BrF3N2O2. It is a derivative of pyridine, featuring a bromine atom, a nitro group, and a trifluoromethyl group. 2-Bromo-3-nitro-5-(trifluoromethyl)pyridine is recognized for its unique chemical structure and reactivity, making it a versatile building block in the synthesis of a variety of chemical compounds.

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  • 1214336-90-9 Structure
  • Basic information

    1. Product Name: 2-Bromo-3-nitro-5-(trifluoromethyl)pyridine
    2. Synonyms: 2-Bromo-3-nitro-5-(trifluoromethyl)pyridine
    3. CAS NO:1214336-90-9
    4. Molecular Formula: C6H2BrF3N2O2
    5. Molecular Weight: 270.9914896
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1214336-90-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 243℃
    3. Flash Point: 101℃
    4. Appearance: /
    5. Density: 1.879
    6. Refractive Index: N/A
    7. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    8. Solubility: N/A
    9. PKA: -5.67±0.20(Predicted)
    10. CAS DataBase Reference: 2-Bromo-3-nitro-5-(trifluoromethyl)pyridine(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-Bromo-3-nitro-5-(trifluoromethyl)pyridine(1214336-90-9)
    12. EPA Substance Registry System: 2-Bromo-3-nitro-5-(trifluoromethyl)pyridine(1214336-90-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1214336-90-9(Hazardous Substances Data)

1214336-90-9 Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-3-nitro-5-(trifluoromethyl)pyridine is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and reactivity contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Bromo-3-nitro-5-(trifluoromethyl)pyridine serves as an intermediate in the production of agrochemicals, aiding in the creation of compounds that can be used in pest control and crop protection.
Used in Biological Research:
2-Bromo-3-nitro-5-(trifluoromethyl)pyridine is utilized in biological research for studying its potential anti-inflammatory and anti-cancer properties. Its unique chemical features make it a candidate for further exploration in medicinal chemistry and drug discovery.
Used as a Building Block in Organic Synthesis:
Owing to its reactive functional groups, 2-Bromo-3-nitro-5-(trifluoromethyl)pyridine is employed as a versatile building block in organic synthesis. It allows for the construction of diverse chemical compounds, expanding the scope of synthetic chemistry and potentially leading to new materials and pharmaceuticals.

Check Digit Verification of cas no

The CAS Registry Mumber 1214336-90-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,4,3,3 and 6 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1214336-90:
(9*1)+(8*2)+(7*1)+(6*4)+(5*3)+(4*3)+(3*6)+(2*9)+(1*0)=119
119 % 10 = 9
So 1214336-90-9 is a valid CAS Registry Number.

1214336-90-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Bromo-3-nitro-5-(trifluoromethyl)pyridine

1.2 Other means of identification

Product number -
Other names 2-bromo-3-nitro-5-trifluoromethyl-pyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1214336-90-9 SDS

1214336-90-9Relevant articles and documents

Pyridine and Pyrazine derivative for the Treatment of CF, COPD, and Bronchiectasis

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Paragraph 0583, (2020/12/18)

The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat bronchiectasis, cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Pyridine derivative PIM kinase inhibitor and preparation method therefor and application thereof in pharmacy

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Paragraph 0191; 0192; 0193; 0194, (2016/10/07)

The present invention provides a PIM kinase inhibitor and a preparation method therefor and an application thereof. The PIM kinase inhibitor is a compound with the structural formula shown in the formula I (the formula is shown in description). The present invention further provides a stereoisomer, a tautomer and pharmaceutical salt of the compound shown in the formula I. According to the present invention, the compound has an obvious inhibition effect on kinase activity. The PIM kinase inhibitor can be used for preparing drugs for curing or preventing cancer, autoimmune diseases, allergic reaction diseases or organ transplant rejection resistance and the like, and the PIM kinase inhibitor has relatively large value in clinical application.

HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CYSTIC FIBROSIS

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Page/Page column 80; 81, (2013/03/28)

The present invention provides pyridin-oxadiazole/thiadiazole derivatives of Formula I wherein A is N or CR 4a; and (ii) or (iii) which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

PYRIDINE AMIDE DERIVATIVES

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Page/Page column 52, (2013/03/28)

The present invention provides pyridine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory

Pyridine amide derivatives

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Page/Page column 48, (2013/03/28)

The present invention provides pyridine amide derivatives which re? store or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, resp

PYRIDINE/PYRAZINE AMIDE DERIVATIVES

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Page/Page column 50, (2013/03/28)

The present invention provides pyridine/pyrazine amide derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthm

N-SUBSTITUTED HETEROCYCLYL CARBOXAMIDES

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Page/Page column 62, (2013/03/28)

A compound of Formula I and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, Ra, A, B, D and E are all as defined herein. The compounds modulate the activity of CFTR and are useful in

Pyridine and Pyrazine derivative for the Treatment of CF

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Page/Page column 32, (2011/10/10)

The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

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