1215107-61-1 Usage
Uses
Used in Pharmaceutical Research:
1-(Pyrimidin-2-yl)cyclopropanamine hydrochloride is used as a precursor in the synthesis of biologically active compounds for [reasons such as enhancing the development of new drugs and understanding their mechanisms of action].
Used in Drug Synthesis:
1-(Pyrimidin-2-yl)cyclopropanamine hydrochloride is used as a key intermediate in the production of pharmaceuticals for [reasons such as its ability to form a variety of active molecules with potential therapeutic effects].
Used in Therapeutic Applications:
1-(Pyrimidin-2-yl)cyclopropanamine hydrochloride is used as a therapeutic agent for the treatment of certain diseases for [reasons such as its demonstrated efficacy in treating specific conditions and its improved pharmacokinetic properties due to the hydrochloride salt form].
Used in Pharmaceutical Industry:
1-(Pyrimidin-2-yl)cyclopropanamine hydrochloride is used in the pharmaceutical industry for [various applications such as drug development, improving drug formulations, and enhancing the understanding of drug mechanisms].
Used in Research and Development:
1-(Pyrimidin-2-yl)cyclopropanamine hydrochloride is used as a research tool for understanding the biological activity of related compounds for [reasons such as its structural features that allow for the exploration of compound interactions with biological targets and the potential to discover new therapeutic agents].
Check Digit Verification of cas no
The CAS Registry Mumber 1215107-61-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,5,1,0 and 7 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1215107-61:
(9*1)+(8*2)+(7*1)+(6*5)+(5*1)+(4*0)+(3*7)+(2*6)+(1*1)=101
101 % 10 = 1
So 1215107-61-1 is a valid CAS Registry Number.
1215107-61-1Relevant academic research and scientific papers
Development of a Scalable Route for a Highly Polar Heterocyclic Aminocyclopropyl Building Block
Abele, Stefan,Ahmetovic, Muhamed,Fleischer, Tony,Sch?fer, Gabriel
, p. 1735 - 1742 (2020/10/26)
A robust and scalable route toward key heterocyclic building block 1-(pyrimidin-2-yl)cyclopropan-1-amine hydrochloride from cyclopropanated starting material 1-amino-1-cyclopropanecarbonitrile hydrochloride was successfully developed. The key to success was the construction of a pyrimidine ring via cyclization from an amidine intermediate and a bench-stable 2-chloro vinamidinium hexafluorophosphate salt. The cyclization was performed under mild conditions, and the resulting 4-cloropyrimidine derivative was isolated in high yield and purity. The final hydrogenation was intensively optimized: A combination of Pd(OH)2/C as a catalyst and NaOMe as a base at 1 bar H2 pressure in MeOH simultaneously cleaved the Cbz group and dechlorinated the pyrimidine ring while at the same time suppressing the over-reduction of the pyrimidine ring to below 1.0%. After acidification with HCl, followed by removal of the catalyst and NaCl by filtration, the final product was isolated in high yield and purity as a bench-stable off-white solid. The overall yield of the five-step sequence was 57%.
Design, synthesis and antibacterial activity studies of novel quinoline carboxamide derivatives
Shivaraj, Yellappa,Naveen, Malenahalli H.,Vijayakumar, Giriyapura R.,Kumar, Doyijode B. Aruna
, p. 241 - 245 (2013/07/25)
A series of novel quinoline-6-carboxamides and 2-chloroquinoline-4- carboxamides were synthesized by the reaction of their analogous carboxylic acids with various amine derivatives in the presence of base TEA and protecting agent BOP at room temperature.
