121554-14-1

Benzamides were converted into benzonitriles with BrCCl3- PPh3-Et3N in CH2Cl2 in an Appel-type reaction. Benzaldoximes could be transformed to benzonitriles under identical conditions. It was found that the reaction system BrCCl3-(2 equiv.)PPh3 was also suitable for these transformations with PPh 3 replacing Et3N.

Disclosed is a use of a quinazoline compound of Formula I having 2,4-diaminoquinazoline as a parent nucleus in preparation of a medicament for treating diseases caused by flaviviridae infection, especially a use in combating Hepatitis C virus infection and Dengue fever virus infection.

In recent years we have used palladium-catalysed cross-coupling procedures to prepare a large number of very interesting lateral mono- and di-fluoro-substituted terphenyls.Similar methodology has been applied in the synthesis of lateral cyano-substituted terphenyls to assess the extent to which the mesophases of such systems can tolerate the larger cyano group; the synthetic routes to these compounds are discussed in detail.The compounds with the lateral cyano-substituent in the centre ring have very low melting points and liquid crystal phases exhibited (SC, SA and nematic) are dependent on the terminal substituents.The compounds with the cyano-substituent at the edge of the terphenyl core are still quite low melting and they have very wide SA ranges. Keywords: lateral cyano-substitution, 1,1':4',1''-terphenyls, palladium-catalysed cross-coupling