- NOVEL SPIRO IMIDAZOLONES AS GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE
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The present invention relates to compounds of the general formula: wherein ring A, ring B, R1, R3, Z, L1, and L2 are selected independently of each other and are as defined herein, to compositions comprising the compounds, and to methods of using the compounds as glucagon receptor antagonists and for the treatment or prevention of type 2 diabetes and conditions related thereto.
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Page/Page column 121-122
(2011/10/13)
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- Phenylalanine derivative and proteinase inhibitor
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A phenylalanine derivative having the formula (I): X represents hydrogen, (b) hydroxy, (c) nitro, or (d) C?-C? alkyloxy which may be substituted with phenyl; Y represents wherein R1 and R2 are, independently, (a) hydrogen, provided that both R1 and R2 are not hydrogen at the same time; (b) phenyl, which may be substituted with (i) phenylcarbonyl, (ii) C?-C? alkylcarbonyl, (iii) C?-C? alkyl, which may be further substituted with C?-C? alkoxycarbonyl or hydroxycarbonyl, (iv) C?-C? alkenyl, which may further be substituted with C?-C? alkoxy-carbonyl, (v) trifluoromethyl; (c) pyridyl, which may be substituted with C?-C? alkoxy; (d) C?-C? alkyl, which may be substituted with (i) hydroxy, (ii) C?-C? alkoxycarbonyl, (iii) pyridyl, or (iv) phenyl, which may be further substituted with C?-C? alkylaminocarbonyl; (e) C?-C? cycloalkyl, which may be substituted with C?-C? alkyl; or (f) R1 and R2 may form, with the nitrogen atom attached thereto, (i) piperidino, which may be substituted with phenylcarbonyl or (ii) pyrrolidyl, which may be substituted with C?-C? alkoxycarbonyl; or a pharmaceutically acceptable salt thereof. This phenylalanine derivative is effective as a proteinase inhibitor.
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