Epimerization of 2- or 4- substituted cyclohexanecarboxylic acids
The present invention relates to a new method for obtaining a purity of about 93% to 100% of the trans form of 2- or 4-substituted cyclohexanecarboxylic acid or reactive derivatives thereof from the cis form or a mixture of the cis and trans forms by a single step, particularly, to a method for obtaining a purity of substantially 100% of the trans form of 4-substituted cyclohexanecarboxylic acid.
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(2008/06/13)
ASYMMETRIC 1,4-ADDITIONS OF GILMAN REAGENTS TO α,β-DISUBSTITUTED (E)-ENOYLSULTAMS / "ENOLATE" PROTONATIONS.
Successive treatment of (E)-Cα,Cβ-disubstituted N-enoyl sultams 6 and 13 with organocopper reagents (Me2CuLi, (CH2=CH)2CuLi, Ph2CuLi in the presence of PBu3 or SCN(1-)) and aq.NH4Cl gave products 7 and 14, respectively, with good to excellent stereoface d
Oppolzer, Wolfgang,Kingma, Arend J.,Poli, Giovanni
p. 479 - 488
(2007/10/02)
Preparation and anticancer activity of 2-diethylaminoethyl-cis- and -trans-methylcyclohexanecarboxylates.
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Harmon,Meulman,Gupta
p. 871 - 872
(2007/10/06)
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