cas 121679-20-7, 3,4-Dihydro Naratriptan (Naratriptan Impurity B)

Articles about 121679-20-7Total 7 be found

The photoredox-catalyzed hydrosulfamoylation of styrenes and its application in the novel synthesis of naratriptan
The hydrosulfamoylation of diverse aryl olefins provides facile access to alkylsulfonamides. Here we report a novel protocol utilizing radical-mediated addition and a thiol-assisted strategy to achieve the hydrosulfamoylation of diverse styrenes in modest to excellent yields under mild and economic reaction conditions. The methodology was found to provide an efficient and convenient approach for the synthesis of the anti-migraine drug naratriptan and it also can be used for the late-stage functionalization of natural products or medicines.
Zhang, Mingjun,Chen, Miaomiao,Ding, Xin,Kang, Jin,Gao, Yongyue,He, Xingxing,Wang, Ziwen,Lu, Aidang,Wang, Qingmin
p. 9140 - 9143
(2021/09/14)

An efficient synthetic protocol for the synthesis of 2-(1H-Indol-5-yl)-ethanesulfonic acid methylamide: A potential synthetic precursor for naratriptan and its novel 3-substituted derivatives
Background: The 3-Substituted indoles are found to possess a wide range of biological and pharmacological activities. The efficient and impurity free scalable preparation of 2-(1H-Indol-5-yl)-ethanesulfonic acid methylamide has been successfully achieved
Behera, Ajaya Kumar,Majumdar, Poulomi,Mohanta, Prajna Parimita,Mishra, Sushanta Kumar
p. 265 - 269
(2018/04/20)

A PROCESS FOR THE SYNTHESIS OF NARATRIPTAN
The present invention relates to a process for preparing naratriptan or a salt thereof, the process comprising: (a) reacting a compound of formula (3) with a compound of the formula HCCR wherein Z is a protecting group, Y is a leaving group and R is a trialkyl silyl group, a trialkylstannyl group or a zinc (II) halide, to obtain the compound of formula (4); (b) converting the compound of formula (4) to a compound of formula (5) wherein Z'' is hydrogen or a benzyl group; (c) converting the compound of formula (5) to naratriptan; and (d) optionally converting naratriptan to a salt thereof. The present invention also provides novel compounds (3) and (4) and processes for their preparation.
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(2011/04/13)

PROCESS FOR PREPARING INDOLE DERIVATIVES
The present invention provides a process for the preparation of indole derivatives, specifically N- methyl-1H-indole-5-ethanesulfonamide of formula (I), involving novel intermediate, which is used as key intermediate for the synthesis of naratriptan of formula (II), and its pharmaceutically acceptable salts thereof high yield and purity.
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Page/Page column 19

(2010/04/03)

PROCESS FOR PREPARATION OF NARATRIPTAN HYDROCHLORIDE
The present invention relates to an improved process for the preparation of N-methyl-3- (1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide hydrochloride of formula (I) having less than 0.15 % area by HPLC of 3-(1-methyl-4-piperidinyl)-1H-indole-5- ethanesulfonamide (1A) and intermediates thereof.
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Page/Page column 27

(2009/10/22)

An investigation into the formation of impurity B during the optimization of naratriptan hydrochloride
During the process development of naratriptan hydrochloride we have made an unusual observation about the enhanced levels of intermediate 3 as an impurity (impurity B) in the final stage. Detailed investigation has led to the conclusion that impurity B is
Kumar, U. Sampath,Sankar, V. Ravi,Kumar, S. Bharani,Prabhu, M. Pandi,Rao, S. Mahender
experimental part
p. 468 - 470
(2010/04/22)

PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES
The present invention relates to a novel process for the preparation of indole derivatives. In particular, present invention relates to the process for preparing naratriptan of formula (I), and its salts using novel intermediates. The present invention also relates to novel synthetic intermediates useful in the preparation of naratriptan hydrochloride.
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Page/Page column 15-16

(2008/12/06)