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121679-24-1

(E)-N-Methyl-2-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]ethenesulfonamide, commonly known as E-4031, is a sulfonamide chemical compound with significant pharmaceutical potential. It is recognized for its role as a potassium channel blocker, which is particularly valuable in the research and treatment of cardiac arrhythmias and related disorders. E-4031 exerts its pharmacological effects by inhibiting the rapidly activating delayed rectifier potassium current (IKr), thereby prolonging the cardiac action potential duration. (E)-N-Methyl-2-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]ethenesulfonamide has demonstrated promise in managing specific heart conditions and has been a subject of interest in preclinical and clinical trials for its antiarrhythmic properties. However, the potential for side effects and contraindications with E-4031 underscores the need for careful consideration in its application.

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  • (E)-N-Methyl-2-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]ethenesulfonamide

    Cas No: 121679-24-1

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  • 2-[3-(1-Methyl-piperidin-4-yl)-1H-indol-5-yl]-ethenesulfonic acid methylamide

    Cas No: 121679-24-1

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  • 121679-24-1 Structure

  • Basic information

    1. Product Name: (E)-N-Methyl-2-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]ethenesulfonamide
    2. Synonyms: (E)-N-Methyl-2-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]ethenesulfonamide;(E)-N-Methyl-2-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)ethenesulfonamide
    3. CAS NO:121679-24-1
    4. Molecular Formula: C17H23N3O2S
    5. Molecular Weight: 333.45
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 121679-24-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 544.7 °C at 760 mmHg
    3. Flash Point: 283.2 °C
    4. Appearance: /
    5. Density: 1.258
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (E)-N-Methyl-2-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]ethenesulfonamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: (E)-N-Methyl-2-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]ethenesulfonamide(121679-24-1)
    11. EPA Substance Registry System: (E)-N-Methyl-2-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]ethenesulfonamide(121679-24-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 121679-24-1(Hazardous Substances Data)

121679-24-1 Usage

Uses

Used in Pharmaceutical Research and Development:
E-4031 is utilized as a potassium channel blocker in the context of pharmaceutical research and development. It is applied for its ability to modulate the rapidly activating delayed rectifier potassium current (IKr), which is integral to the study and potential treatment of cardiac arrhythmias.
Used in Cardiology:
In the field of cardiology, E-4031 is used as an antiarrhythmic agent. It serves to manage certain heart conditions by affecting the electrical properties of the heart, specifically by prolonging the cardiac action potential duration, which can help in the regulation of abnormal heart rhythms.
Used in Clinical Trials:
E-4031 is also used in clinical trials to evaluate its efficacy and safety in treating arrhythmias. These trials are crucial for understanding the compound's potential side effects and establishing its place in therapeutic strategies for heart conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 121679-24-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,1,6,7 and 9 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 121679-24:
(8*1)+(7*2)+(6*1)+(5*6)+(4*7)+(3*9)+(2*2)+(1*4)=121
121 % 10 = 1
So 121679-24-1 is a valid CAS Registry Number.

121679-24-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name N-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethenesulfonamide

1.2 Other means of identification

Product number -
Other names (E)-N-METHYL-2-[3-(1-METHYL-4-PIPERIDINYL)-1H-INDOL-5-YL]ETHENESULFONAMIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:121679-24-1 SDS

121679-24-1Upstream product

121679-24-1Downstream Products

121679-24-1Relevant articles and documents

Indole derivatives

-

, (2008/06/13)

Compounds are disclosed of formula (I) STR1 wherein R1 represents H or C1-6 alkyl; R2 represents H or C1-6 alkyl; R3 represents H; R4 represents H or C1-3 alkyl; and pharmaceutically acceptable salts and solvates (for example hydrates thereof. The compounds are indicated as useful for the treatment of migraine, cluster headache, chronic paroxysmal hemicrania and headache associated with vascular disorders. Processes and intermediates for their preparation and pharmaceutical compositions containing them are also disclosed.

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