ASYMMETRIC ALDOL REACTION OF α-ISOCYANOACETAMIDES WITH ALDEHYDES CATALYZED BY A CHIRAL FERROCENYLPHOSPHINE-GOLD(I) COMPLEX
Aldol reaction of N,N-dialkyl-α-isocyanoacetamides with primary alkyl aldehydes in the presence of 0.5-1 molpercent of a chiral (aminoalkyl)ferrocenylphosphine-gold(I) catalyst proceeded with high enantio- and diastereoselectivity to give trans-5-alkyl-2-oxazoline-4-carboxamides of up to 98.6percent ee, which were converted into optically active threo-β-hydroxyamino acids.