Orally Active Aldose Reductase Inhibitors Derived from Bioisosteric Substitutions on Tolrestat
A series of aldose reductase inhibitors was prepared in which structural modifications were made to three positions of the potent, orally active inhibitor tolrestat (1), namely, the 6-methoxy substituent, thioamide sulfur, and the N-methyl moiety.These co
Wrobel, Jay,Millen, Jane,Sredy, Janet,Dietrich, Arlene,Kelly, Joseph M.,et al.
p. 2493 - 2502
(2007/10/02)
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