Discovery and SAR of substituted 3-oxoisoindoline-4-carboxamides as potent inhibitors of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer
Through conformational restriction of a benzamide by formation of a seven-membered hydrogen-bond with an oxindole carbonyl group, a series of PARP inhibitors was designed for appropriate orientation for binding to the PARP surface. This series of compound
Gandhi, Viraj B.,Luo, Yan,Liu, Xuesong,Shi, Yan,Klinghofer, Vered,Johnson, Eric F.,Park, Chang,Giranda, Vincent L.,Penning, Thomas D.,Zhu, Gui-Dong
scheme or table
p. 1023 - 1026
(2010/06/14)
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