- A novel method for the synthesis of actarit
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The specific synthetic route to synthesize the actarit (4-acetyl-amino phenylacetic acid) by acylation was designed in which p-amino benzaldehyde (a) and nitromethane (b) was used as the raw materials, through Knoevenagel reaction. The selective reduction of potassium borohydride and p-amino phenylacetic acid to be oxidated under the acidic conditions. After optimization of the synthetic conditions, the yield of each step was more than 85 %. The synthesized compound was confirmed by the elemental analysis and nuclear magnetic resonance. Because of the readily available raw materials, simple operations, high yield and avoiding highly toxic reagents in the synthesis of actarit (4-acetyl-amino phenylacetic acid), the synthetic route is suitable for the industrial production.
- Zhou, Li-Yi,Yang, Jun,Yan, Xi-Qing,Pan, Yan-Juan,Wu, Feng,Zhang, Jing,Yan, Fu-Lin,Lu, Guang-Zhou
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experimental part
p. 1538 - 1540
(2012/10/07)
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- Highly chemo- and regioselective reduction of aromatic nitro compounds using the system silane/oxo-rhenium complexes
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(Chemical Equation Presented) The reduction of aromatic nitro compounds to the corresponding amines with silanes catalyzed by high valent oxo-rhenium complexes is reported. The catalytic systems PhMe2SiH/ReIO 2(PPh3)2 (5 mol %) and PhMe2SiH/ ReOCl3(PPh3)2 (5 mol %) reduced efficiently a series of aromatic nitro compounds in the presence of a wide range of functional groups such as ester, halo, amide, sulfone, lactone, and benzyl. This methodology also allowed the regioselective reduction of dinitrobenzenes to the corresponding nitroanilines and the reduction of an aromatic nitro group in presence of an aliphatic nitro group. 2009 American Chemical Society.
- De Noronha, Rita G.,Romao, Carlos C.,Fernandes, Ana C.
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supporting information; experimental part
p. 6960 - 6964
(2010/03/03)
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- REDUCTION OF AROMATIC NITROALKENES WITH BAKER'S YEAST
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Aromatic nitroalkenes were reduced chemoselectively with baker's yeast to give the corresponding nitroalkanes.
- Takeshita, Mitsuhiro,Yoshida, Sachiko,Kohno, Yoichiro
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p. 553 - 562
(2007/10/02)
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- SELECTIVE AND SEQUENTIAL REDUCTION OF NITROAROATICS BY MONTMORILLONITESILYLAMINEPALLADIUM(II) COMPLEX
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Nitroaromatics are sequently and selectively hydrogenated in quantitative yields at room temperature and atmospheric pressure by interlamellarmontmorillonitepalladium(II) complex, a heterogenised homogenous catalyst.
- Mukkanti, K.,Rao, Y. V. Subba,Choudary, B. M.
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p. 251 - 252
(2007/10/02)
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