- Preparation method and application of tricetin
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The invention belongs to the field of medicine synthesis, and in particular relates to a preparation method and application of tricetin. The method comprises the following steps: performing hydroxy protection to form a compound 3 by using 2,4,6-trihydroxyacetophenone as a starting material, performing an acylation reaction on the compound 3 and 3,4,5-trimethoxybenzoyl chloride to form a compound 4, performing Baker-Venkataranan rearrangement on the compound 4 to form a compound 5, performing cyclization on the compound 5 under catalysis of H2SO4/HOAc to form a compound 6, and finally performing pyridine hydrochloride deprotection on the compound 6 to form the tricetin, wherein in the step of synthesizing the compound 5, when NaOH is selected as a base and pyridine is selected as a solvent,the yield is greatly improved, and the reaction is relatively stable. According to the method provided by the invention, pharmacological activity experiments show that the compound synthesized by themethod has anti-nerve damage activity, so that the compound has better application prospects in treating nerve damage-related diseases.
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Paragraph 0007; 0063; 0066; 0067
(2019/10/01)
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- Flavonoids with M1 muscarinic acetylcholine receptor binding activity
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Muscarinic acetylcholine receptor- Active compounds have potential for the treatment of Alzheimer's disease. In this study, a series of natural and synthetic flavones and flavonols was assayed in vitro for their ability to inhibit radioligand binding at human cloned M1 muscarinic receptors. Several compounds were found to possess competitive binding affinity (K i = 40-110 μM), comparable to that of acetylcholine (Ki = 59 μM). Despite the fact that these compounds lack a positively-charged ammonium group under physiological conditions, molecular modelling studies suggested that they bind to the orthosteric site of the receptor, mainly through non-polar interactions.
- Swaminathan, Meyyammai,Chee, Chin Fei,Chin, Sek Peng,Buckle, Michael J. C.,Rahman, Noorsaadah Abd.,Doughty, Stephen W.,Chung, Lip Yong
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p. 8933 - 8948
(2014/08/05)
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- Constituents of the Root Bark of Murraya paniculata Collected in Indonesia
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A mixture of fatty acid esters (Va) of murrangatin was obtained from the root bark of Murraya paniculata (Rutaceae) collected in Indonesia together with eleven known constituents of chemotaxonomical significance, and their structures were characterized on
- Imai, Fujio,Itoh, Kikuo,Kishibuchi, Noriko,Kinoshita, Takeshi,Sankawa, Ushio
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p. 119 - 123
(2007/10/02)
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- The Preparation of Flavones and their Derivatives. Part I. Flavones and 4-Thioflavones.
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A series of polysubstituted flavones has been prepared with particular emphasis on 3',4',5',5,7-pentahydroxyflavone and its ether derivatives.The preparation of 4-thioflavones has been undertaken to provide intermediates for the preparation of 4-iminoflav
- Briggs, Malcolm T.,Duncan, Graham L. S.,Thornber, Craig W.
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p. 2461 - 2487
(2007/10/02)
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