A green approach for highly regioselective syntheses of furo[3,2-h]quinolines in aqueous medium
An environmentally benign, high yielding, and operationally simple protocol has been developed for the regioselective synthesis of furo[3,2-h]quinolines in aqueous micellar medium involving Cu-free domino Sonogashira reaction followed by 5-endo-dig-cyclization of substituted 8-hydroxyquinolines and terminal alkyne by using Pd(C6H5CN)Cl2 as catalyst and 2-pyridinecarboxaldehyde methylphenyl hydrazone as ligand under aerobic condition.
One-pot tandem synthesis of Furo[3,2- h ]quinolines by a sonogashira cross-coupling and cyclization reaction supported by basic alumina under microwave irradiation
Acetylenic 8-quinolinols generated in situ by the Sonogashira cross-coupling reaction are efficiently converted into furo[3,2-h]quinolines by microwave-assisted, copper-catalyzed, intramolecular cyclization in the presence of basic alumina. Georg Thieme Verlag Stuttgart New York.