- Direct arylation of Imidazo[l,2-b]pyridazines: microwave-assisted one-pot Suzuki coupling/Pd-catalysed arylation
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Direct intermolecular C-H arylation of 6-chloroimidazo [ 1,2 - b] pyridazine in its 3-position was achieved, and the tolerance to reaction conditions in the presence of chloro groups was investigated. Various 3-(hetero)arylimidazo[l,2-b]pyridazines were synthesized in good to excellent yields. This methodology was successfully applied to the synthesis of 3,6-diand 2,3,6-trisubstituted imidazo[l,2-5]pyridazines by a microwave-assisted, one-pot, two-step Suzuki cross-coupling/ palladium-catalysed arylation process.
- Akkaoui, Ahmed El,Berteina-Raboin, Sabine,Mouaddib, Abderrahim,Guillaumet, Gerald
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experimental part
p. 862 - 871
(2010/04/05)
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