Chemoenzymatic synthesis of an α-substituted serine derivative
An asymmetric synthesis of an α-substituted serine derivative was achieved by employing PLE-catalyzed hydrolysis of a prochiral malonate derivative, and the absolute configuration of the hydrolyzed product was unambiguously determined by the X-ray analysis of a camphorsulfonic acid derivative.
OXIDATIVE DEPROTONATION OF CARBONYL COMPOUNDS BY Fe(III) SALTS
Iron (III) salts (perchlorate and nitrate nonahydrate) in acetonitrile or acetic anhydride at 0-50 deg C oxidize the α-position of malonic esters efficiently via the corresponding radicals.In the presence of olefins and aromatics, inter- and intramolecular free radical chain or oxidative additions are observed.