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1220973-37-4

AKP-11 is a highly potent and selective inhibitor of bromodomain and extra-terminal domain (BET) proteins, which are crucial in gene regulation. This small molecule effectively inhibits the binding of BET proteins with chromatin, leading to the suppression of key oncogenes and proliferation-related genes. It exhibits anti-proliferative and anti-inflammatory properties, making it a promising candidate for the treatment of various cancers and inflammatory diseases. Additionally, AKP-11 has demonstrated good pharmacokinetic properties and is well-tolerated in preclinical studies, highlighting its potential as a therapeutic agent for a range of diseases.
Used in Pharmaceutical Industry:
AKP-11 is used as an anti-cancer agent for its ability to suppress the activity of key oncogenes and proliferation-related genes, making it a promising candidate for the treatment of various cancers.
AKP-11 is also used as an anti-inflammatory agent for its ability to exhibit anti-inflammatory properties, making it a potential treatment for various inflammatory diseases.
Used in Drug Development:
AKP-11 is used as a therapeutic agent in preclinical studies for its good pharmacokinetic properties and well-tolerated nature, indicating its potential for further development and application in treating a range of diseases.

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  • 1220973-37-4 Structure

  • Basic information

    1. Product Name: AKP-11
    2. Synonyms: AKP-11
    3. CAS NO:1220973-37-4
    4. Molecular Formula: C22H22ClN3O5
    5. Molecular Weight: 443.88018
    6. EINECS: -0
    7. Product Categories: N/A
    8. Mol File: 1220973-37-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 684.0±65.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.370±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 11.68±0.20(Predicted)
    10. CAS DataBase Reference: AKP-11(CAS DataBase Reference)
    11. NIST Chemistry Reference: AKP-11(1220973-37-4)
    12. EPA Substance Registry System: AKP-11(1220973-37-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1220973-37-4(Hazardous Substances Data)

1220973-37-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1220973-37-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,0,9,7 and 3 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1220973-37:
(9*1)+(8*2)+(7*2)+(6*0)+(5*9)+(4*7)+(3*3)+(2*3)+(1*7)=134
134 % 10 = 4
So 1220973-37-4 is a valid CAS Registry Number.

1220973-37-4Downstream Products

1220973-37-4Relevant articles and documents

ORGANIC COMPOUNDS

-

, (2014/05/24)

Novel benzofuran derivatives are disclosed. The derivatives have S1P1 receptor activity and/or disease modifying activity and find use in the treatment of conditions or diseases associated with the immune, vascular and nervous systems in animals and/or humans

S1P RECEPTORS MODULATORS AND THEIR USE THEREOF

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Page/Page column 88, (2010/04/30)

The invention relates to novel compounds that have S1P receptor modulating activity. Further, the invention relates to a pharmaceutical comprising at least one compound of the invention for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression, for example, autoimmune response. A further aspect of the invention relates to the use of a pharmaceutical comprising at least one compound of the invention for the manufacture of a medicament for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression such as autoimmune response.

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