- Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists
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Transient receptor potential melastatin 8 (TRPM8) is a nonselective cation channel that is thermoresponsive to cool to cold temperatures (8-28 ° C) and also may be activated by chemical agonists such as menthol and icilin. Antagonism of TRPM8 activation i
- Parks, Daniel J.,Parsons, William H.,Colburn, Raymond W.,Meegalla, Sanath K.,Ballentine, Shelley K.,Illig, Carl R.,Qin, Ning,Liu, Yi,Hutchinson, Tasha L.,Lubin, Mary Lou,Stone, Dennis J.,Baker, Judith F.,Schneider, Craig R.,Ma, Jianya,Damiano, Bruce P.,Flores, Christopher M.,Player, Mark R.
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p. 233 - 247
(2011/03/22)
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- HETEROCYCLIC BENZIMIDAZOLES AS TRPM8 MODULATORS
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Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein W1, W2, W3, R1/s
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Page/Page column 80
(2010/04/30)
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