122384-65-0 Usage
Uses
Used in Pharmaceutical Industry:
Formamide, N-[[5-(1-methylethyl)-1,2,4-oxadiazol-3-yl]methyl](9CI) is used as a central nervous system depressant for its potential calming and sedative effects. It is being studied for its ability to reduce anxiety and promote relaxation without causing significant side effects.
Used in Anticonvulsant Applications:
In the field of neurology, Formamide, N-[[5-(1-methylethyl)-1,2,4-oxadiazol-3-yl]methyl](9CI) is used as a potential anticonvulsant agent. It has shown promise in managing seizures and reducing the frequency of epileptic episodes, offering a potential alternative treatment for patients suffering from epilepsy.
Used in Antitumor Applications:
Formamide, N-[[5-(1-methylethyl)-1,2,4-oxadiazol-3-yl]methyl](9CI) is used as an antitumor agent in oncology research. Its potential to inhibit the growth of cancer cells and reduce tumor size has been observed in preliminary studies, making it a candidate for further investigation in the development of cancer therapies.
Used in Antifungal Applications:
In the field of microbiology, Formamide, N-[[5-(1-methylethyl)-1,2,4-oxadiazol-3-yl]methyl](9CI) is used as an antifungal agent. It has demonstrated the ability to inhibit the growth of various fungi, which could lead to the development of new treatments for fungal infections.
Used in Chemical Industry:
Formamide, N-[[5-(1-methylethyl)-1,2,4-oxadiazol-3-yl]methyl](9CI) is used as a chemical intermediate in the synthesis of various compounds. Its unique structure and properties make it a valuable building block for the development of new pharmaceuticals, agrochemicals, and other specialty chemicals.
More research is needed to fully understand and characterize the properties and potential applications of Formamide, N-[[5-(1-methylethyl)-1,2,4-oxadiazol-3-yl]methyl](9CI). Its diverse range of potential uses highlights the importance of continued investigation into this promising compound.
Check Digit Verification of cas no
The CAS Registry Mumber 122384-65-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,3,8 and 4 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 122384-65:
(8*1)+(7*2)+(6*2)+(5*3)+(4*8)+(3*4)+(2*6)+(1*5)=110
110 % 10 = 0
So 122384-65-0 is a valid CAS Registry Number.
122384-65-0Relevant articles and documents
High-affinity partial agonist imidazo[1,5-a]quinoxaline amides, carbamates, and ureas at the γ-aminobutyric acid A/benzodiazepine receptor complex
Jacobsen, E. Jon,TenBrink, Ruth E.,Stelzer, Lindsay S.,Belonga, Kenneth L.,Carter, Donald B.,Im, Haesook K.,Im, Wha Bin,Sethy, Vimala H.,Tang, Andy H.,VonVoigtlander, Philip F.,Petke, James D.
, p. 158 - 175 (2007/10/03)
A series of imidazo[1,5-a]quinoxaline amides, carbamates, and ureas which have high affinity for the γ-aminobutyric acid A/benzodiazepine receptor complex was developed. Compounds within this class have varying efficacies ranging from antagonists to full
Novel Benzodiazepine Receptor Partial Agonists: Oxadiazolylimidazobenzodiazepines
Watjen, Frank,Baker, Raymond,Engelstoff, Mogens,Herbert, Richard,MacLeod, Angus,et al.
, p. 2282 - 2291 (2007/10/02)
The synthesis and biochemical evaluation of a series of oxadiazole derivatives of imidazobenzodiazepines related to the benzodiazepine antagonist Ro 15-1788 (2a) are reported.Although the oxadiazole ring is seen as an isosteric replacement for the ester linkage, significant differences in structure-activity trends were observed.Specifically, oxadiazoles 9-12 invariably had increased receptor efficacy (as witnessed by measurements of the GABA shift) relative to the corresponding ester.Additionally, and in direct contrast to the classical agonists such as diazepam, affinity for the benzodiazepine receptor was enhanced by a 7- rather than 8-halo substituent.The results are discussed in terms of a six-point receptor-binding model originally based on the X-ray structure of 2a.For comparison, the crystal structures of two representative oxadiazole derivatives, 10h and 12o, having a 6-oxo and 6-phenyl group, respectively, were determined and the data incorporated into a modified binding model to account for the greater efficacy of these compounds.It is concluded that the antagonist behavior of 2a relies upon the hydrogen-bond-acceptor properties of the ester carbonyl oxygen whereas for the oxadiazole series this site is localized at the imidazole nitrogen.
