The Mechanism of Cytochrome P-450 Dependent C-C Bond Cleavage: Studies on 17α-Hydroxylase-17,20-lyase
It is shown that formation of 17α-hydroxyandrost-5-en-3β-ol from pregnenolone occurs solely at the expense of the cleavage of the C-17-C-20 bond of the precursor and is best rationalised by invoking the participation of an FeIII-OOH intermediate in the acyl-carbon fission process.
Corina, David L.,Miller, Sharon L.,Wright, J. Neville,Akhtar, Muhammad
p. 782 - 783
(2007/10/02)
Formation of 5,16-androstadien-3β-ol from pregnenolone in human testicular microsomes
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Kohara
p. 295 - 309
(2007/10/02)
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