Reversible Inhibitors of the Gastric (H+/K+)-ATPase. 2. 1-Arylpyrroloquinolines: Effect of the 4-Substituent
Further work on compounds 1 has identified the 4-position as a site where substantial modifications are tolerated, leading to analogues which are more potent and less toxic than those described previously.The best compound in the series is 13a (SKandF 963
Leach, Colin A.,Brown, Thomas H.,Ife, Robert J.,Keeling, David J.,Laing, Shiona M.,et al.
p. 1845 - 1852
(2007/10/02)
DIHYDROPYRROLO QUINOLINE DERIVATIVES
1,4-Substituted 2,3-dihydropyrrolo[3,2-c]quinolines which are inhibitors of H+ K+ ATPase activity and useful as inhibitors of gastric acid secretion. A compound of the invention is 1-(2-methylphenyl)-4-amino-6-methyl-2,3-dihydropyrrolo[3,2-c]quinoline.
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(2008/06/13)
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