A versatile catalyst for intermolecular direct arylation of Indoles with benzoic acids as arylating reagents
(Figure Presented) Coupled together: With a versatile catalyst system (Pd(TFA)2/Ag2CO3/propionic acid) both electron-rich and -deficient benzoic acids serve as arylating reagents for the direct functionalization of a wide rage of indoles by a combination of decarboxylation and C-H bond activation. Depending on the nature of the benzoic acids, the reaction occurs selectively at either the C2- or C3-position of indoles, which may arise from two different catalytic pathways (see scheme; TFA = trifluoroacetate).
Direct C-3 arylation of N-acetylindoles with anisoles using phenyliodine bis(trifluoroacetate) (PIFA)
The direct C-3 arylation of N-acetylindoles with anisoles was described in this Letter. In the presence of phenyliodine bis(trifluoroacetate) (PIFA) and BF3·Et2O, the reaction of N-acetylindoles with anisoles provided C-3 arylindoles with high regioselectivity under mild conditions.
Gu, Yonghong,Wang, Dawei
scheme or table
p. 2004 - 2006
(2010/06/21)
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