- Photoinduced upregulation of calcitonin gene-related peptide in A549 cells through HNO release from a hydrophilic photocontrollable HNO donor
-
Nitroxyl (HNO), a one-electron-reduced form of nitric oxide, has various biological activities, including a cardioprotective effect. Here, we first synthesized another, more hydrophilic photocontrollable HNO donor (3), which can release HNO in a spatially and temporally controlled manner, and then examined the properties of our series of compounds as practical HNO donors in a cellular system under photocontrol. We selected compound 2 as the preferred donor, and used it to show that calcitonin gene-related peptide (CGRP) can be upregulated in A549 cells via photocontrolled HNO release. This result demonstrates the suitability of this photocontrollable HNO donor for biological investigations.
- Matsuo, Kazuya,Nakagawa, Hidehiko,Adachi, Yusuke,Kameda, Eri,Aizawa, Kazuyuki,Tsumoto, Hiroki,Suzuki, Takayoshi,Miyata, Naoki
-
experimental part
p. 1055 - 1062
(2012/09/25)
-