Synthesis of (-)-actinonin in 17% overall yield was accomplished in seven steps via the formation of an isoimide derivative as the key intermediate. The synthesis was carried out using commercially available dimethyl maleate without the use of a highly expensive reagent. Georg Thieme Verlag Stuttgart - New York.
Asymmetric Synthesis of (-)-Actinonin and (-)-epi-Actinonin
The highly asymmetric induction imparted by the iron chiral auxiliary 5-C5H5)Fe(CO)(PPh3)> is exploited in the preparation of homochiral (R)- and (S)-α-pentylsuccinates.Their application in the synthesis of (-)-actinonin and (-)-epi-actinoni
Bashiardes, George,Bodwell, Graham J.,Davies, Stephen G.
p. 459 - 470
(2007/10/02)
THE ASYMMETRIC SYNTHESIS OF (-)-ACTINONIN USING THE IRON CHIRAL AUXILIARY 5-C5H5)Fe(CO)(PPh3)>
The asymmetric synthesis of the α-pentyl succinate fragment of (-)-Actinonin is achived using the chiral ironacetyl S-(+)-5-C5H5)-Fe(CO)(PPh3)COCH3> and subsequently converted to (-)-Actinonin in an overall yield of 41percent.
Bashiardes, George,Davies, Stephen G.
p. 6509 - 6512
(2007/10/02)
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