- Non-natural nucleosides based on 1,2,4-triazolo[1,5-a]pyrimidin-7-ones
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Two methods for synthesis of new nucleosides bearing 6-phenyl-l,2,4- triazolo[l,5-a]pyrimidin-7-ones as a base have been developed. The first one includes Vorbrggen glycosylation reaction. The second method, which is effective for synthesis of acyclic nucleosides, is based on the condensation between sodium salts of 6-phenyl-1,2,4-triazolo [1,5-a]pyrimidin-7-ones and 4-bromobuthyl acetate or (Z)-4-bromobut-2-en-1-yl acetate.
- Chupakhin, Oleg N.,Shestakova, Tatiana S.,Deev, Sergey L.,Eltsov, Oleg S.,Rusinov, Vladimir L.
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experimental part
p. 1149 - 1163
(2010/10/04)
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- 1,2,4-Triazoloazine derivatives as a new type of herpes simplex virus inhibitors
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A new class of inhibitors of herpes simplex virus replication was found. The compounds under study are derived from condensed 1,2,4-triazolo[5,1-c][1,2, 4]triazines and 1,2,4-triazolo[1,5-a]pyrimidines, structural analogues of natural nucleic bases. Antih
- Deev,Yasko,Karpenko,Korovina,Khandazhinskaya,Andronova,Galegov,Shestakova,Ulomskii,Rusinov,Chupakhin,Kukhanova
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experimental part
p. 265 - 270
(2011/02/22)
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