1226985-36-9

Basic information

• Product Name: 3H-Indazol-3-one, 6-bromo-1,2-dihydro-1-methyl-
• CAS NO: 1226985-36-9
• Mol File: 1226985-36-9.mol

Chemical Properties

• CAS DataBase Reference: 3H-Indazol-3-one, 6-bromo-1,2-dihydro-1-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-Indazol-3-one, 6-bromo-1,2-dihydro-1-methyl-(1226985-36-9)
• EPA Substance Registry System: 3H-Indazol-3-one, 6-bromo-1,2-dihydro-1-methyl-(1226985-36-9)

Safety Data

• Hazardous Substances Data: 1226985-36-9(Hazardous Substances Data)

Upstream product

• 60-34-4 methylhydrazine 
• 179232-29-2 methyl 4-bromo-2-fluorobenzoate 
• 112704-79-7 2-fluoro-4-bromobenzoic acid 
• 66584-32-5 3-bromo-N-methylaniline 
• 22038-72-8 methyldiazene 
• 17405-06-0 N-(3-bromophenyl)-N-methylnitrous amide 

Relevant articles and documents

INDAZOLE COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION

Indazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease states associated with glutamate dysfunction.

Rhodium(III)-catalyzed N-nitroso-directed C-H addition to ethyl 2-oxoacetate for cycloaddition/fragmentation synthesis of indazoles

RhIII-catalyzed N-nitroso-directed C-H addition to ethyl 2-oxoacetate allows subsequent construction of indazoles, a privileged heterocycle scaffold in synthetic chemistry, through the exploitation of reactivity between the directing group and installed group. The formal [2+2] cycloaddition/fragmentation reaction pathway identified herein, a unique reactivity pattern hitherto elusive for the N-nitroso group, emphasizes the importance of forward reactivity analysis in the development of useful C-H functionalization-based synthetic tools. The synthetic utility of the protocol is demonstrated with the synthesis of a tri-cyclic-fused ring system. The diversity of covalent linkages available for the nitroso group should enable the extension of the genre of reactivity reported herein to the synthesis of other types of heterocycles.

NOVEL COMPOUNDS AND COMPOSITIONS FOR INHIBITION OF FASN

The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

A general, one-step synthesis of substituted indazoles using a flow reactor

Flow chemistry is a rapidly emerging technology within the pharmaceutical industry, both within medicinal and development chemistry groups. The advantages of flow chemistry, increased safety, improved reproducibility, enhanced scalability, are readily apparent, and we aimed to exploit this technology in order to provide small amounts of pharmaceutically interesting fragments via a safe and scalable route, which would enable the rapid synthesis of multigram quantities on demand. Here we report a general and versatile route which utilises flow chemistry to deliver a range of known and novel indazoles, including 3-amino and 3-hydroxy analogues.

COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS

This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.