Efficient One-Pot Synthesis of Mono- and Bis[di(2-pyridyl)phosphine Oxides] from Tris(2-pyridyl)phosphine
An efficient one-pot access to di(2-pyridyl)phosphine oxides Py2P(R)=O and bis[di(2-pyridyl)phosphine oxides] Py2P(O)-Z-P(O)Py has been developed based on the reaction of available tris(2-pyridyl)phosphine with various organic halides, followed by treatment of the resulting phosphonium salts with alkali in situ. The isolated yields of the phosphine oxides were in the range 40-96%.
Malysheva, Svetlana F.,Gusarova, Nina K.,Belogorlova, Nataliya A.,Sutyrina, Anastasiya O.,Litvintsev, Yuriy I.,Albanov, Alexander I.,Sterkhova, Irina V.,Artem'ev, Alexander V.
FORMATION OF 2,2'-BIPYRIDYL BY LIGAND COUPLING ON THE PHOSPHORUS ATOM
Phosphonium salts and phosphine oxides, bearing at least two 2-pyridyl or substituted 2-pyridyl groups gave the corresponding 2,2'-bipyridyls and pyridines upon treatment with acid or neutral solvents such as water and alcohols, in substantial yields.
Uchida, Yuzuru,Kozawa, Hideaki,Oae, Shigeru
p. 6365 - 6368
(2007/10/02)
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