Synthesis and pharmacological properties of N-thienyl alkylenediamines
A series of N-thienylalkylenediamines was synthesized and tested for their analgesic, anti-inflammatory and anti-pyretic activities, as well as for their acute toxicity and central effects.Acetylsalicylic acid, phenylbutazone and indomethacin were used as reference drugs.Several compounds showed interesting aspirin-like properties associated with good systemic and gastric tolerance.Keywords: 2-nitrothiophenes / N-thienyl alkylenediamines / anti-inflammatory activity / analgesic activity / basic anti-inflammatory agents
Ronsisvalle, Giuseppe,Pappalardo, Maria S.,Vittorio, Franco,Pasquinucci, Lorella,Caruso, Antonina,et al.
p. 553 - 560
(2007/10/02)
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