122799-98-8Relevant articles and documents
AZOLOPYRIDINE AND AZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF
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Page/Page column 163-164, (2012/03/26)
Provided herein are azolopyridine and azolopyrimidine compounds for treatment of JAK kinase mediated diseases, including JAK2 kinase-, JAK3 kinase- or TYK2 kinase-mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.
Substituted pyrazolopyrimidines
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Page/Page column 15-16, (2008/06/13)
The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted heterobicyclic pyrimidines of Formula (I): wherein R1, R2, R3, R4, R5, X, W, and ring A are as defined herein; pharmaceutical compositions of substituted heterobicyclic pyrimidines of Formula (I); and their use in the treatment of chronic neurodegenerative diseases, neurotraumatic diseases, depression and/or diabetes. More particularly, the present invention relates to substituted pyrazolopyrimidines of Formula (I).
Synthesis and Pharmacological Evaluation of a Series of 4-Piperazinylpyrazolo- and -benzodiazepines as Potential Anxiolytics
Chakrabarti, Jiban K.,Hotten, Terrence M.,Pullar, Ian A.,Tye, Nicholas C.
, p. 2573 - 2582 (2007/10/02)
The synthesis and pharmacological evaluation of a series of pyrazolobenzodiazepines are described.Some of the 4-piperazinyl-2,10-dihydropyrazolobenzodiazepine derivatives demonstrated potent anxiolytic activity in the three-part operan