- Synthesis and SAR of 4-aminocyclopentapyrrolidines as orally active N-type calcium channel inhibitors for inflammatory and neuropathic pain
-
A novel series of N-type calcium channel inhibitors have been discovered. Optimization of potency and HT-ADME properties provides 4- aminocyclopentapyrrolidines with analgesic efficacy after oral dosing.
- Beebe, Xenia,Yeung, Clinton M.,Darczak, Daria,Shekhar, Shashank,Vortherms, Timothy A.,Miller, Loan,Milicic, Ivan,Swensen, Andrew M.,Zhu, Chang Z.,Banfor, Patricia,Wetter, Jill M.,Marsh, Kennan C.,Jarvis, Michael F.,Scott, Victoria E.,Schrimpf, Michael R.,Lee, Chih-Hung
-
p. 4857 - 4861
(2013/09/02)
-
- NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA[C]PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS
-
The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein L1, L2, R1, R2, and R3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
- -
-
Page/Page column 44
(2010/06/14)
-
- N-ALKYL-AZACYCLOALKYL NMDA/NR2B ANTAGONISTS
-
Compounds represented by Formula (I): and/or pharmaceutically acceptable salts, individual enantiomers and stereoisomers thereof, are effective as NMDA/NR2B antagonists useful for treating conditions such as pain, Parkinson’s disease, Alzheimer’s disease, epilepsy, depression, anxiety, ischemic brain injury including stroke.
- -
-
Page/Page column 28; 69
(2008/06/13)
-