One-step and Solvent-free synthesis of terpene-fused pyrazines
Solvent-free condensation reactions were carried out by heating terpene-monooximes with an excess of amines. Employing camphor-and nopinone-derived monooximes, two classes of terpene-fused pyrazine derivatives were synthesized. Besides being solvent-free, the described one-step procedure can be directed towards terpene-fused imidazole or pyrazine derivatives. Whereas the reaction worked well with arylmethanamines bearing a (hetero)aromatic substituent at the α-carbon, alkylamines afforded only imino-oximes. A possible reaction path is presented.
Kulhanek, Jiri,Ludwig, Miroslav,Bures, Filip
experimental part
p. 315 - 322
(2010/08/04)
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