POTENTIAL ANTIDEPRESSANTS: SYNTHESIS OF TWO 4-(AMINOALKOXY)DIBENZOTHIEPIN-11(6H)-ONES
Heating of 4-methoxydibenzothiepin-11(6H)-one with pyridine hydrochloride to 225 to 235 deg C effected demethylation and gave IV.Its sodium salt reacted with 3-dimethylaminopropyl chloride in ethanol and afforded the 4-(3-dimethylaminopropoxy) compound II.The isomeric ether III was prepared via the 4-(4-bromobutoxy) compound V.Hydrochloride of II (VUFB-17033) inhibitied mildly the binding of 3H>desipramine in rat hypothalamus, had antireserpine activity in rats, mild anticonvulsant effect, and antihypoxic effect in the test of nitrogen anoxia in mice.
Cervena, Irena,Holubek, Jiri,Svatek, Emil,Metys, Jan,Valchar, Martin,Protiva, Miroslav
p. 225 - 228
(2007/10/02)
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