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CAS

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123040-75-5

6-Chloro-3,4-dihydro-3-oxo-2H-1,4-benzoxazine-8-carboxylic acid methyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 6-Chloro-3,4-dihydro-3-oxo-2H-1,4-benzoxazine-8-carboxylic acid methyl ester

    Cas No: 123040-75-5

  • USD $ 1.9-2.9 / Gram

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  • 123040-75-5 Structure

  • Basic information

    1. Product Name: 6-Chloro-3,4-dihydro-3-oxo-2H-1,4-benzoxazine-8-carboxylic acid methyl ester
    2. Synonyms: 6-Chloro-3,4-Dihydro-3-Oxo-2H-1,4-Benzoxazine-8-CarboxylicAcidMethylEster;2H-1,4-Benzoxazine-8-carboxylic acid, 6-chloro-3,4-dihydro-3-oxo-, Methyl ester;Methyl 6-chloro-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxylate
    3. CAS NO:123040-75-5
    4. Molecular Formula: C10H8ClNO4
    5. Molecular Weight: 241.63
    6. EINECS: N/A
    7. Product Categories: Intermediate of azasetron hcl;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
    8. Mol File: 123040-75-5.mol

  • Chemical Properties

    1. Melting Point: 239-241 ºC
    2. Boiling Point: 451.489 °C at 760 mmHg
    3. Flash Point: 226.853 °C
    4. Appearance: /
    5. Density: 1.424
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 6-Chloro-3,4-dihydro-3-oxo-2H-1,4-benzoxazine-8-carboxylic acid methyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: 6-Chloro-3,4-dihydro-3-oxo-2H-1,4-benzoxazine-8-carboxylic acid methyl ester(123040-75-5)
    11. EPA Substance Registry System: 6-Chloro-3,4-dihydro-3-oxo-2H-1,4-benzoxazine-8-carboxylic acid methyl ester(123040-75-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 123040-75-5(Hazardous Substances Data)

123040-75-5 Usage

Uses

Intermediate in the preparation of Azasetron.

Check Digit Verification of cas no

The CAS Registry Mumber 123040-75-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,0,4 and 0 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 123040-75:
(8*1)+(7*2)+(6*3)+(5*0)+(4*4)+(3*0)+(2*7)+(1*5)=75
75 % 10 = 5
So 123040-75-5 is a valid CAS Registry Number.

123040-75-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name Methyl 6-chloro-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxylate

1.2 Other means of identification

Product number -
Other names methyl 6-chloro-3-oxo-4H-1,4-benzoxazine-8-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:123040-75-5 SDS

123040-75-5Relevant articles and documents

Optimization of triazoles as novel and potent nonphlorizin SGLT2 inhibitors

Du, Xiaohui,Lizarzaburu, Mike,Turcotte, Simon,Lee, Taeweon,Greenberg, Joanne,Shan, Bei,Fan, Peter,Ling, Yun,Medina, Julio C.,Houze, Jonathan

, p. 3774 - 3779 (2011/08/06)

Previous efforts have led to the identification of a potent, selective, and nonphlorizin based SGLT2 inhibitor 1. This Letter describes efforts to further optimize the potency, microsomal stability, solubility and pharmacokinetic properties of this series of SGLT2 inhibitors. From these efforts, compounds 28 and 32 have improved solubility and pharmacokinetic properties compared to compound 1.

Synthesis and pharmacology of 3,4-dihydro-3-oxo-1,4-benzoxazine-8-carboxamide derivatives, a new class of potent serotonin-3 (5-HT3) receptor antagonists

Kawakita,Kuroita,Yasumoto,Sano,Inaba,Fukuda,Tahara

, p. 624 - 630 (2007/10/02)

A series of 3,4-dihydro-3-oxo-1,4-benzoxazine-8-carboxamide derivatives was synthesized and evaluated for serotonin-3 (5-HT3) receptor antagonistic activity assessed by their ability to antagonize the von Bezold-Jarish (BJ) effect in rats. Derivatives bearing 1-azabicyclo[2.2.2]oct-3-yl moiety as a basic function attached to the carboxamide at position 8 showed more potent antagonistic activity than those bearing the other three basic moieties. Structure activity relationships of this series showed that methyl and chloro groups were more effective as substituents at positions 4 and 6, respectively. The representative compound 15 (Y-25130) in this series showed potent antagonistic activity on the BJ effect (ED50 = 1.3 μg/kg i.v.), high affinity for 5-HT3 receptor (K(i) = 2.9 nM) and complete protection against cisplatin-induced emesis in dogs at a dose of 0.1 mg/kg i.v.

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