123054-31-9Relevant articles and documents
Synthesis of 3-hydroxycephems from penicillin G through cyclization of chlorinated 4-(phenylsulfonylthio)-2-azetidinones promoted by a BiCl3/Sn or TiCl4/Sn bimetal redox system
Tanaka,Taniguchi,Kameyama,Monnin,Torii,Sasaoka,Shiroi,Nagao,Yamada,Tokumaru
, p. 1385 - 1391 (2007/10/02)
A novel access to 3-hydroxycephems was attained from penicillin G via the C=C bond cleavage of 1-(1-alkoxycarbonyl-2-chloromethyl-2-propenyl)-4-(phenylsulfonylthio)- 2-azetidinones by successive treatment with RuCl3/HIO4 and HIO4/CuSO4 and reductive cyclization of I-(I-alkoxycarbonyl-3-chloro-2-hydroxy-1-propenyl)-4-(phenylsulfonylth io)-2-azetidinones on treatment with a newly devised BiCl3/Sn or TiCl4/Sn bimetal redox couple in DMF containing pyridine.
A Facile Access to 3-Hydroxycephems from Penicillin G through Bi/Sn or Ti/Sn Redox-Promoted Cyclization of 4-(Phenylsulfonylthio)azetidinones
Tanaka, Hideo,Taniguchi, Masatoshi,Kameyama, Yutaka,Monnin, Marc,Sasaoka, Michio,et al.
, p. 1867 - 1868 (2007/10/02)
Direct conversion of 1-(3-chloro-2-hydroxy-1-p-methoxybenzyloxycarbonyl-1-propenyl)-4-(phenylsulfonylthio)azetidinones derived from penicillin G into 3-hydroxycephems was performed successfully by the action with BiCl3/Sn or TiCl4/Sn bimetal redox couples in DMF containing pyridine.