- CRYSTAL FORM OF ABEMACICLIB MESYLATE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITION THEREOF
-
Disclosed is a crystal form of abemaciclib mesylate, which has one or more improved properties compared with the known abemaciclib mesylate. Also involved are a method for preparing the crystal form of abemaciclib mesylate, a pharmaceutical composition and the use of same in the preparation of a drug for treating cancer diseases such as colorectal cancer, breast cancer, lung cancer, prostate cancer, glioblastoma, mantle cell lymphoma, chronic granulocytic leukemia and acute granulocytic leukemia.
- -
-
Paragraph 0165-0170; 0171-0185
(2021/06/22)
-
- Novel synthesis method of Abemaciclib mesylate
-
The invention discloses a synthesis method of Abemaciclib mesylate. The method comprises steps as follows: (1), a compound 9 in the description is subjected to a reaction with a compound 5 in the description under the action of strong base, and a compound
- -
-
-
- COMBINATION THERAPY FOR CANCER
-
The present invention provides preparation of medicaments for use in treating and methods of treating non-small cell lung cancer in a patient comprising: [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-[5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3H- benzoimidazol-5-yl)-pyrimidin-2-yl]-amine, or a pharmaceutically acceptable salt thereof, in combination, as further described herein, with an anti-VEGFR2 antibody, preferably, ramucirumab.
- -
-
-
- PROTEIN KINASE INHIBITORS
-
The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof which is useful in the treatment of cell proliferative diseases.
- -
-
Page/Page column 18
(2010/07/04)
-
