- PROCESSES FOR MAKING PONATINIB AND INTERMEDIATES THEREOF
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Methods are disclosed for making 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-l-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide, intermediates and pharmaceutically acceptable salts thereof.
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Page/Page column 7; 9; 10; 11; 13
(2016/12/26)
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- A new crystalline form of acetylenic aryl compound
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The invention relates to a method for preparing 3-ethynylimidazo[1,2-b]pyridazine (a compound 2). The method comprises the step of mixing 4-(imidazo[1,2-b]pyridazine-3-yl)-2-methyl-3-butyne-2-ol (a compound 3) with alkali for reacting in a solvent. According to the method for preparing the compound 2 from the compound 3, the compound 3 is in a solid state and is stable in properties, and can be used as a medicine intermediate; due to cheap and easily available raw material 2-methyl-3-butyne-2-ol or other reagents needed by preparing the compound 3, the cost is low; the reaction is mild in conditions and suitable for industrial production.
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Paragraph 0056-0058
(2017/06/02)
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- CRYSTALLINE FORMS OF PONATINIB HYDROCHLORIDE
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The present disclosure relates to polymorphic forms of the hydrochloride salt of ponatinib ( compound 1 ) and to processes for the preparation of these polymorphic forms. The present disclosure also generally relates to a pharmaceutical composition comprising the forms, as well of methods of using the form(s) in the treatment of disorders associated with pathological cellular proliferation, such as neoplasms, and cancer.
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Page/Page column 14
(2015/01/16)
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- MODIFICATIONS OF 3-(2-IMIDAZO[1,2-B]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-[4-[(4-METHYL-1-PIPERAZINYL)METHYL]-3-(TRIFLUOROMETHYL)PHENYL] BENZAMIDE HYDROCHLORIDE SALT
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Crystal modifications and amorphous form of ponatinib hydrochloride. Formula (I)
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Page/Page column 20
(2015/06/25)
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- CRYSTALLINE FORMS OF 3-(IMIDAZO[1,2-B] PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-(4-[(4-METHYLPIPERAZIN-1-YL) METHYL]-3-(TRIFLUOROMETHYL)PHENYL)BENZAMIDE AND ITS MONO HYDROCHLORIDE SALT
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Novel crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4- methylpiperazin-1 -yl)methyl]-3-(trifluoromethyl)phenyl}benzamide free base and 3-(imidazo[1,2- b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3
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- PROCESSES FOR MAKING PONATINIB AND INTERMEDIATES THEREOF
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Novel synthetic approaches to make 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide, intermediates and pharmaceutically acceptable salts thereof are provided.
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Paragraph 0074; 0095; 0095
(2014/12/09)
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- METHODS AND COMPOSITIONS FOR RAF KINASE MEDIATED DISEASES
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The invention discloses methods and compositions for treating or preventing RAF kinase mediated diseases or conditions by administering a compound of Formula 1: or a pharmaceutically acceptable salt, solvate or hydrate thereof, wherein the variables are defined as herein.
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Page/Page column 55; 70
(2013/11/18)
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