123312-22-1 Usage
Uses
Used in Organic Synthesis:
(4-CHLOROPHENYL)(CYCLOPROPYL)METHYLAMINE is used as a building block in organic synthesis for the preparation of a range of biologically active compounds. Its unique structure allows it to be a key component in the creation of new organic molecules with potential applications across different fields.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (4-CHLOROPHENYL)(CYCLOPROPYL)METHYLAMINE is utilized as an intermediate in the development of pharmaceuticals. Its properties contribute to the synthesis of drugs that target specific biological pathways, potentially leading to the discovery of new treatments for various diseases.
Used in Agrochemical Production:
(4-CHLOROPHENYL)(CYCLOPROPYL)METHYLAMINE also finds application in the agrochemical sector, where it serves as an intermediate in the synthesis of compounds used in agriculture to protect crops from pests and diseases, thereby increasing crop yields and ensuring food security.
Used in the Development of New Materials:
(4-CHLOROPHENYL)(CYCLOPROPYL)METHYLAMINE's reactivity and structural features make it a candidate for the development of new materials with unique properties. These materials could have applications in various industries, including electronics, plastics, and coatings.
Used in Chemical Process Development:
(4-CHLOROPHENYL)(CYCLOPROPYL)METHYLAMINE plays a role in the innovation of chemical processes, potentially leading to more efficient and sustainable methods for producing chemicals and compounds essential for various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 123312-22-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,3,1 and 2 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 123312-22:
(8*1)+(7*2)+(6*3)+(5*3)+(4*1)+(3*2)+(2*2)+(1*2)=71
71 % 10 = 1
So 123312-22-1 is a valid CAS Registry Number.
123312-22-1Relevant articles and documents
Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases
Addie, Matt,Ballard, Peter,Buttar, David,Crafter, Claire,Currie, Gordon,Davies, Barry R.,Debreczeni, Judit,Dry, Hannah,Dudley, Philippa,Greenwood, Ryan,Johnson, Paul D.,Kettle, Jason G.,Lane, Clare,Lamont, Gillian,Leach, Andrew,Luke, Richard W. A.,Morris, Jeff,Ogilvie, Donald,Page, Ken,Pass, Martin,Pearson, Stuart,Ruston, Linette
, p. 2059 - 2073 (2013/05/08)
Wide-ranging exploration of analogues of an ATP-competitive pyrrolopyrimidine inhibitor of Akt led to the discovery of clinical candidate AZD5363, which showed increased potency, reduced hERG affinity, and higher selectivity against the closely related AGC kinase ROCK. This compound demonstrated good preclinical drug metabolism and pharmacokinetics (DMPK) properties and, after oral dosing, showed pharmacodynamic knockdown of phosphorylation of Akt and downstream biomarkers in vivo, and inhibition of tumor growth in a breast cancer xenograft model.
PYRROLO [2,3-D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS
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Page/Page column 85, (2009/05/30)
The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I)
