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CAS

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1233335-78-8

Sofosbuvir metabolites GS566500 are a group of organic compounds that result from the breakdown of the antiviral medication sofosbuvir in the body. As a prodrug, sofosbuvir is metabolized in the liver to form GS566500, which is an important intermediate in the conversion process to its active form. These metabolites play a crucial role in the pharmacokinetics and pharmacodynamics of sofosbuvir, contributing to its therapeutic effectiveness and potential side effects in the treatment of hepatitis C virus infections.

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  • (2S)-2-({[(2R,3R,4R,5R)-5-(2,4-dioxo-3H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy(hydroxy)phosphoryl}amino)propanoic acid

    Cas No: 1233335-78-8

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  • 1233335-78-8 Structure

  • Basic information

    1. Product Name: Sofosbuvir metabolites GS566500
    2. Synonyms: Sofosbuvir metabolites GS566500;GS-566500;PSI 352707;N-[(2'R)-2'-Deoxy-2'-fluoro-2'-methyl-5'-uridylyl]-L-alanine;(2S)-2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)amino)propanoic acid;Sofosbuvir Impurity 49 (GS-566500);(2S)-2-(((((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)amino)propanoic Acid Ammonium Salt;O-Desisopropyl O-Desphenyl Sofosbuvir Ammonium Salt
    3. CAS NO:1233335-78-8
    4. Molecular Formula: C13H19FN3O9P
    5. Molecular Weight: 411.2768242
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1233335-78-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Sofosbuvir metabolites GS566500(CAS DataBase Reference)
    10. NIST Chemistry Reference: Sofosbuvir metabolites GS566500(1233335-78-8)
    11. EPA Substance Registry System: Sofosbuvir metabolites GS566500(1233335-78-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1233335-78-8(Hazardous Substances Data)

1233335-78-8 Usage

Uses

Used in Hepatitis C Treatment:
Sofosbuvir metabolites GS566500 are used as an intermediate in the conversion of sofosbuvir to its active form, which is essential for the treatment of hepatitis C virus infections. The metabolites contribute to the drug's therapeutic effectiveness by enhancing its antiviral activity and reducing the viral load in infected patients.
Used in Pharmaceutical Research and Development:
Understanding the formation, metabolism, and elimination of GS566500 is crucial for optimizing the use of sofosbuvir in the treatment of hepatitis C virus infections. Researchers and pharmaceutical companies utilize this knowledge to develop more effective and safer antiviral medications, as well as to improve the pharmacokinetic and pharmacodynamic properties of existing drugs.
Used in Drug Metabolism Studies:
Sofosbuvir metabolites GS566500 serve as a model for studying drug metabolism and the role of metabolites in the pharmacokinetics and pharmacodynamics of medications. This information is valuable for predicting the behavior of other prodrugs and their metabolites, as well as for designing new drugs with improved efficacy and reduced side effects.
Used in Toxicology and Safety Assessment:
The study of GS566500 metabolites also plays a role in toxicology and safety assessment of sofosbuvir. By understanding the potential side effects and toxicological properties of these metabolites, researchers can better evaluate the safety profile of the drug and identify strategies to minimize adverse effects in patients.

Check Digit Verification of cas no

The CAS Registry Mumber 1233335-78-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,3,3,3,3 and 5 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1233335-78:
(9*1)+(8*2)+(7*3)+(6*3)+(5*3)+(4*3)+(3*5)+(2*7)+(1*8)=128
128 % 10 = 8
So 1233335-78-8 is a valid CAS Registry Number.

1233335-78-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name Sofosbuvir metabolites GS566500

1.2 Other means of identification

Product number -
Other names (2S)-2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)amino)propanoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1233335-78-8 SDS

1233335-78-8Upstream product

1233335-78-8Downstream Products

1233335-78-8Relevant articles and documents

NUCLEOSIDE ANALOGS

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Page/Page column 32-33, (2010/07/09)

A purified compound having activity against hepatitis C virus is disclosed.

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