Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1
An efficient synthesis of 29 new binaphthyl-based neutral, and mono- and di-cationic, peptoids is described. Some of these compounds had antibacterial activities with MIC values of 1.9-3.9 μg/mL against Staphylococcus aureus. One peptoid had a MIC value of 6 μg/mL against a methicillin-resistant strain of S. aureus (MRSA) and a MIC value of 2 μg/mL against vancomycin-resistant strains of enterococci (VRE).
Bremner, John B.,Keller, Paul A.,Pyne, Stephen G.,Boyle, Timothy P.,Brkic, Zinka,David, Dorothy M.,Robertson, Mark,Somphol, Kittiya,Baylis, Dean,Coates, Jonathan A.,Deadman, John,Jeevarajah, Darshini,Rhodes, David I.
supporting information; experimental part
p. 2611 - 2620
(2010/06/16)
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