- Synthesis and biological screening of novel derivatives of 3-(N-substituted carboxamidoethylthio)-(4H)-1,2,4-triazoles
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3-Mercapto-(4H)-1,2,4-triazole has been synthesized from 1-formylthiosemicarbazide. Different N-substituted β-chloropropionamides have been prepared by reacting substituted amines with β- chloropropionylchloride. Different Nsubstituted β-chloropropionamides have been condensed with 3-mercapto-(4H)-1,2,4-triazole in basic medium to obtain various 3-(N-substituted carboxamidoethylthio)-(4H)-1,2,4-triazoles. The structure of the synthesized compounds are confirmed by IR, 1H NMR spectra and elemental analysis. All the compounds have been screened for their analgesic, anti-inflammatory and anxiolytic activity.
- Manikrao, Anil M.,Fursule, Ravindra A.,Rajesh,Kunjwani, Harish K.,Sabale, Prafulla M.
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p. 1642 - 1647
(2011/03/17)
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- Synthesis and antimicrobial evaluation of 3-(N-substituted carboxamidoethylthio)-(4H)-1,2,4-triazoles
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A series of 3-(N-substituted carboxamidoethylthio)-(4H)-1,2,4-triazoles (6) were synthesized under microwave irradiation and also by conventional method and were characterized by IR, 1H NMR and elemental analysis. The title compounds were subje
- Manikrao,Fursule,Kunjwani,Mahajan,Sable
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experimental part
p. 301 - 302
(2011/12/14)
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