3, 5-DISUBSTITUTED PYRAZOLE COMPOUNDS AS KINASE INHIBITORS AND USES THEREOF
The disclosure provides novel compounds as represented in Formula (I), wherein A0-A2, R0-R6, L, Z and Q are defined herein. The compounds of Formula (I) are CHK1 inhibitors. Therefore, the compounds of the discl
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Page/Page column 22; 32
(2021/03/13)
CHK1/2 INHIBITORS FOR USE IN THE TREATMENT OF NEUROBLASTOMAS AND/OR SOFT TISSUE SARCOMAS
The present invention provides 5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-lH- pyrazol-3-ylamino)pyrazine~2~carbonitrile and pharmaceutically acceptable salts and solvates thereof, that is capable of inhibiting CHK1 and is useful in the treatment of neuroblastomas and/or soft tissue sarcomas.
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Page/Page column 24; 25
(2017/02/09)
COMPOUNDS USEFUL FOR INHIBITING CHK1
The present invention provides an aminopyrazole compound, or a pharmaceutically acceptable salt thereof or a solvate of the salt, that inhibits Chk1 and is useful in the treatment of cancer.
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Page/Page column 12
(2011/06/26)
COMPOUNDS USEFUL FOR INHIBITING CHK1
The present invention provides an aminopyrazole compound, or a pharmaceutically acceptable salt thereof or a solvate of the salt, that inhibits Chk1 and is useful in the treatment of cancer.
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Page/Page column 30-31
(2010/08/04)
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