123506-66-1

Basic information

• Product Name: 5-FORMYL-2-METHOXY-4-PICOLINE
• Synonyms: 5-FORMYL-2-METHOXY-4-PICOLINE;3-Pyridinecarboxaldehyde, 6-methoxy-4-methyl- (9CI);6-methoxy-4-methylnicotinaldehyde;6-Methoxy-4-methyl-3-pyridinecarboxaldehyde
• CAS NO: 123506-66-1
• Molecular Formula: C8H9NO2
• Molecular Weight: 151.16
• Product Categories: ALDEHYDE;Pyridine
• Mol File: 123506-66-1.mol

Chemical Properties

• Boiling Point: 274.173 °C at 760 mmHg
• Flash Point: 119.616 °C
• Appearance: /
• Density: 1.123 g/cm³
• Refractive Index: 1.546
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5-FORMYL-2-METHOXY-4-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FORMYL-2-METHOXY-4-PICOLINE(123506-66-1)
• EPA Substance Registry System: 5-FORMYL-2-METHOXY-4-PICOLINE(123506-66-1)

Safety Data

• Hazardous Substances Data: 123506-66-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-FORMYL-2-METHOXY-4-PICOLINE is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs, leveraging its unique chemical structure to enhance medicinal properties.
Used in Agrochemical Industry:
In the agrochemical sector, 5-FORMYL-2-METHOXY-4-PICOLINE is utilized as an intermediate in the production of agrochemicals, potentially aiding in the creation of more effective and targeted pesticides or other agricultural chemicals.
Used in Dye Industry:
5-FORMYL-2-METHOXY-4-PICOLINE is employed as an intermediate in the synthesis of dyes, where its chemical properties contribute to the development of new dye formulations with specific color characteristics and application properties.
Used in Coordination Chemistry:
5-FORMYL-2-METHOXY-4-PICOLINE is used as a ligand in coordination chemistry, taking advantage of its ability to form complexes with metal ions, which can be applied in various areas such as catalysis, materials science, and sensor development.
Used in Synthesis of Other Organic Compounds:
As a precursor, 5-FORMYL-2-METHOXY-4-PICOLINE is used in the synthesis of other organic compounds, providing a foundation for creating a diverse range of chemical products through further chemical reactions.
Safety Note:
It is important to handle 5-FORMYL-2-METHOXY-4-PICOLINE with care due to its flammable nature and potential harmful effects if inhaled or ingested, necessitating proper safety measures during its use and storage.

InChI:InChI=1/C8H9NO2/c1-6-3-8(11-2)9-4-7(6)5-10/h3-5H,1-2H3

Upstream product

• 65873-72-5 6-methoxy-3-pyridinecarboxaldehyde 
• 74-88-4 methyl iodide 
• 624-28-2 2,5-dibromopyridine 
• 13472-85-0 2-methoxy-5-bromopyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 164513-39-7 5-bromo-2-methoxy-4-methylpyridine 
• 100848-70-2 2-methoxy-4-methyl-pyridine 

Relevant articles and documents

HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES

The invention relates to aryl substituted heterocyclyl sulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Convenient Synthesis of 6-Bromo-1,2,3,4-tetrahydroisoquinoline and 3-Methoxy-1,2,3,4-tetrahydro-[2,7]-naphthyridine via Reductive Amination of Schiff's Bases

Synthesis of 7-bromo-1,2,3,4-tetrahydroisoquinoline and 6-methoxy-1,2,3,4-tetrahydro-[2,7]-naphthyridine via lithiation of 2-methylarylidene-tert-butylamines, followed by formylation, reductive amination in one-pot, and removal of the tert-butyl group fro

NOVEL COMPOUNDS

The invention provides compounds of formula (I): wherein R1, R2, A, A1 and B are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the ph

Lithiation of Methoxypyridines Directed by α-Amino Alkoxides

The addition of methoxypyridinecarboxaldehydes to certain lithium dialkylamides gave α-amino alkoxides in situ that were ring-lithiated with alkyllithium bases.Alkylation and hydrolysis on workup provided ring-substituted methoxypyridinecarboxaldehydes via a one-pot reaction.The one-pot methylation of isomeric methoxypyridinecarboxaldehydes was examined.The regioselectivity of the lithiation-methylation was dependent on the aldehyde, the amine component of the α-amino alkoxide, and the metalation conditions.When lithiated N,N,N'-trimethylethylenediamine was used as the amine component of the α-amino alkoxide, methylation generally occured ortho to the aldehyde function.The analogous reactions using lithium N-methylpiperazide as the amine component gave substitution next to the methoxy group.Several new methylated methoxypyridinecarboxaldehydes were prepared in a regioselective manner by using this one-pot procedure.