123534-58-7

Basic information

• Product Name: 1-(2-bromopyridin-3-yl)propan-1-one
• Synonyms: 1-(2-bromopyridin-3-yl)propan-1-one
• CAS NO: 123534-58-7
• Molecular Formula: C₈H₈BrNO
• Molecular Weight: 214.05922
• Mol File: 123534-58-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-bromopyridin-3-yl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-bromopyridin-3-yl)propan-1-one(123534-58-7)
• EPA Substance Registry System: 1-(2-bromopyridin-3-yl)propan-1-one(123534-58-7)

Safety Data

• Hazardous Substances Data: 123534-58-7(Hazardous Substances Data)

Upstream product

• 153473-77-9 1-(2-bromopyridin-3-yl)propan-1-ol 
• 109-04-6 2-bromo-pyridine 
• 128071-75-0 2-bromopyridine-3-carboxaldehyde 

Downstream Products

• 123534-53-2 2-(4-Chloro-phenyl)-3-methyl-thiopyrano[2,3-b]pyridin-4-one 
• 1371592-13-0 1-(2-(1-benzyl-4-chloroindol-3-yl)pyridin-3-yl)propan-1-one 

Relevant articles and documents

Synthesis of tetracyclic indoles via intramolecular α-arylation of ketones

Figure Persented: An intramolecular palladium(0)-mediated α-arylation of ketones applied to the synthesis of various substituted tetracyclic indoles is reported. Most significantly, the efficiency of the transformation was enhanced by the use of monoligated Pd(0) complexes. This methodology was extended to double α-arylation of ketones using one-pot reactions with either simultaneous addition or sequential addition of two aryl halides for producing aryl substituted tetracyclic indoles.

Discovery, synthesis, and bioactivity of bis(heteroaryl)piperazines. 1. A novel class of non-nucleoside HIV-1 reverse transcriptase inhibitors

A variety of analogues of 1-[4-methoxy-3,5-dimethylbenzyl]-4-[3- (ethylamino)-2-pyridyl]piperazine hydrochloride (U-80493E) were synthesized and evaluated for their inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). Replacement of the substituted aryl moiety with various substituted indoles provided bis(heteroaryl)piperazines (BHAPs) that were 10-100-fold more potent than U-80493E. The pyridyl portion of the lead molecule was found to be very sensitive to modifications. Extensive preclinical evaluations of several of these compounds led to the selection of 1-[(5-methoxyindol-2-yl)carbonyl]-4-[3-(ethylamino)-2- pyridyl]piperazine methanesulfonate (U-87201E, atevirdine mesylate) for clinical evaluation.

A Facile and Concise Synthesis of 2-Alkyl- and 2-Aryl-4-oxo-4H-thiopyranopyridines

2-Alkyl- and 2-aryl-4-oxo-4H-thiopyranopyridine can be conveniently prepared by reacting the appropriate aromatic and aliphatic O-ethyl thiocarboxylates with the sodium derivative of various alkyl 3-(2-bromopyridyl) ketones.