SEPARATION OF ENANTIOMERS OF 3-ETHYLBICYCLO[3.2.0]HEPT-3-EN-6-ONE
A process to isolate a compound of Formula (2a) or a salt or solvate thereof, comprising a) reacting a mixture of diastereoisomers of Formulae (2a, 2b) with a basic heterocyclic-aldehyde compound and an optically active amine in the presence of a base; and b) separating the compound of Formula (2a) from the product of step a) by acid extraction. The compound of Formula (2a) may be produced with an enantiomeric excess of 98%. Compounds of Formula (2a) are useful intermediates in a process to prepare a bicyclic γ - amino tetrazole derivative of Formula (I) which finds utility in treating neuropathic pain and disorders of the central nervous system.
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Page/Page column 20
(2016/10/04)
Optical Resolution Methods for Bicyclic Compounds Using Enzymes
An object of the present invention is to efficiently produce an optically active bicyclic compound. The optically active bicyclic compound is efficiently produced using an enzyme.
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Paragraph 0064-0072
(2015/02/19)
Optical Resolution Method for Bicyclic Compound Using Asymmetric Catalyst
An optically active bicyclic compound is efficiently produced by optical resolution using an optically active amine.
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Paragraph 0072; 0073; 0074; 0075
(2014/10/16)
Method for Producing Bicyclic Compound via Claisen Rearrangement
The problem to be solved by the present invention is to provide a method for producing a compound having excellent activity as an α2δ ligand. The solution thereto is a method for producing a compound represented by the general formula (VI) or a
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Page/Page column
(2014/04/17)
METHOD FOR PRODUCING BICYCLIC GAMMA-AMINO ACID DERIVATIVE
The problem to be solved is to provide a method for producing a compound having excellent activity as an α2δ ligand. The solution thereto is a method for producing a compound represented by the general formula (I) or a salt thereof by optical resolution: [in the formula, R1: a hydrogen atom or a C1-C6 alkyl group, and R2: a hydrogen atom or a protective group for the carboxy group]
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(2012/02/14)
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