- NOVEL SYNTHESIS OF 5-HALOURACILS FROM 5-MERCURI-2,4-DIMETHOXYPYRIMIDINES
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Direct C-mercuration of 2,4-dimethoxypyrimidine with mercury (II) acetate has been shown to give the 5-mercuri-derivative, which is readily converted, either directly or via 5,5'-mercuribis (2,4-dimethoxypyrimidine), into the 5-halo derivatives.Hydrolysis of the latter with hydrochloric acid affords the 5-halouracils.
- Skul'ski, L.,Kuyava, A.,Vrochin'ski, P.
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- Metal-free chlorodeboronation of organotrifluoroborates
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A mild and metal-free method for the chlorodeboronation of organotrifluoroborates using trichloroisocyanuric acid (TCICA) was developed. Aryl-, heteroaryl-, alkenyl-, alkynyl-, and alkyltrifluoroborates were converted into the corresponding chlorinated products in good yields. This method proved to be tolerant of a broad range of functional groups.
- Molander, Gary A.,Cavalcanti, Livia N.
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experimental part
p. 7195 - 7203
(2011/10/13)
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